教师基本信息

姓名：顾正龙

单位：粤港澳大湾区精准医学研究院（广州）

职称：资深研究员

邮箱：guzhenglong@ipm-gba.org.cn

个人页面：https://www.ipm-gba.org.cn/Index/team_details/id/252.html

研究方向

      线粒体与疾病、基因组功能与进化、多基因调控网络的功能和进化等

代表论文

      1. Guo X, Xu W, Zhang W, Pan C, Thalacker-Mercer AE, Zheng H, Gu Z*. High-frequency and functional mitochondrial DNA mutations at the single-cell level. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2201518120. doi: 10.1073/pnas.2201518120.

      2. Pu W, Gu Z*. Incompatibilities between common mtDNA variants in human disease. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2217452119. doi: 10.1073/pnas.2217452119.

      3. Wang Y, Guo X, Hong X, Wang G, Pearson C, Zuckerman B, Clark AG, O'Brien KO, Wang X, Gu Z*. Association of mitochondrial DNA content, heteroplasmies and inter-generational transmission with autism. Nat Commun. 2022 Jul 1;13(1):3790. doi: 10.1038/s41467-022-30805-7.

      4. Wang Y, Guo X, Ye K, Orth M, Gu Z*. Accelerated expansion of pathogenic mitochondrial DNA heteroplasmies in Huntington's disease. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2014610118. doi: 10.1073/pnas.2014610118.

      5. Yang X, Zhang R, Nakahira K, Gu Z*. Mitochondrial DNA Mutation, Diseases, and Nutrient-Regulated Mitophagy. Annu Rev Nutr. 2019 Aug 21;39:201-226. doi: 10.1146/annurev-nutr-082018-124643.